Lucio Gregoretti has composed symphonic and chamber music regularly performed mostly in Europe. He has also composed musical comedies, film scores, and incidental music for theatre plays.
At MacDowell in 2005, he continued work on L'Ultimo Avventore, a stage opera in one act. During his 2006 residency, he realized a new version of P.A.C.E. for chamber orchestra, which would be performed in Italy by the Nuova Orchestra Scarlatti. He also entirely composed Mundus Novus for flute and piano for a CD release containing music by Italian and America composers. During his 2011 residency, Gregoretti worked on a mass for soloists, choir and orchestra commissioned by the Pergolesi Spontini Festival.